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Muscatine Hy-Vee Mainstreet

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Located 2 blocks east of Cedar Street. Converted April 16, 2013, from the Hy-Vee Drugstore to Muscatine Hy-Vee Mainstreet, with more products and services.

Open 7 a.m. to 10 p.m. every day (main store).

510 East Sixth Street
Muscatine, IA 52761
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Phone Numbers:
Store: 563-263-6461
Department Phone Numbers
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Department Hours
Hy-Vee Drugstore Clinic: Monday-Friday 9 a.m.-5 p.m.
Hy-Vee Drugstore Clinic: Mon-Thur 9 a.m.-5 p.m. -
Friday 9 a.m.-1 p.m.
Hy-Vee Home Medical: 9 a.m. - 5 p.m. Monday-Friday
9 a.m. - 12 noon Saturday
Hy-Vee Wine & Spirits: Monday-Saturday 8 a.m.-10 p.m.
Sunday 10 a.m.-9 p.m.
Mainstreet Grill: 7 a.m.-7 p.m. daily
Pharmacy: 8 a.m. - 9 p.m. Mon.-Fri.; 8:30 a.m.- 6 p.m. Sat.; 9 a.m.- 5 p.m. Sunday
Service Meat: 7 a.m. - 8 p.m. daily
Store News
Christmas Hours

Christmas Hours  Read more.

Mainstreet Grill

Enjoy our Mainstreet Grill selections. View our menu!  Read more.


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Calendar of Events
No Upcoming Events
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Dietitian services
At Your Service

If you have a question or need an informed opinion, just ask your Hy-Vee dietitian.

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Department Features

Learn more about the departments and services offered at your Muscatine Hy-Vee Mainstreet and the store management.

Hy-Vee Bakery

No matter what your occasion is, casual to formal, your Hy-Vee caterers do it. Browse our selections for your next special event.

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