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Des Moines Hy-Vee Drugstore

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From Interstate-235, go north on 42nd Street to University Avenue. Go right (east) on University Avenue one block. Store is on the south side of University Avenue.

Open 6 a.m. to midnight daily. Closed Christmas Day.
Wine and Spirits: 8 a.m. to midnight
Pharmacy: 8 a.m to 9 p.m. Monday through Friday, 9 a.m. to 6 p.m. Saturday and Sunday.

4100 University Avenue
Des Moines, IA 50311
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Phone Numbers:
Store: 515-633-8603
Department Phone Numbers
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Online Refills
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Department Hours
Dietitian: Mondays, Tuesdays and Fridays
Pharmacy: 8 a.m. to 9 p.m. Monday-Friday; 9 a.m. to 6 p.m. Saturday & Sunday.
Flu shot schedule -
Monday-Friday 8 a.m.-9 p.m.
Walk-ins welcome.
Wine & Spirits: 8 a.m. to midnight daily
Store News
Flu Shot Schedule

Flu shots available 8 a.m. to 9 p.m. Monday-Friday. Walk-ins welcome.  Read more.

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Calendar of Events
Dietitian Hours

7/7/2015 10:00 a.m. - 6:00 p.m.
Hours your Drugstore dietitian is available. Read more.

Grown in the USA

7/7/2015 4:00 p.m. - 6:00 p.m.
Chat with our dietitian, Courtney, about locally grown foods you can buy right here at your Des Moines Drugstore. Read more.

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Dietitian services
At Your Service

If you have a question or need an informed opinion, just ask your Hy-Vee dietitian.

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Department Features

Learn more about the departments and services offered at your Des Moines Hy-Vee Drugstore and the store management.

Hy-Vee Floral

No matter what your occasion is, casual to formal, your Hy-Vee caterers do it. Browse our selections for your next special event.

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