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Des Moines Hy-Vee Drugstore

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From Interstate-235, go north on 42nd Street to University Avenue. Go right (east) on University Avenue one block. Store is on the south side of University Avenue.

Open 6 a.m. to midnight Monday - Sunday. Closed Christmas Day.
Wine and Spirits hours 8 a.m. to Midnight
Pharmacy hours Monday thru Friday 8 a.m. to 9 p.m. Saturday & Sunday 9 a.m. to 6 p.m.

4100 University Avenue
Des Moines, IA 50311
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Phone Numbers:
Store: 515-633-8603
Department Phone Numbers
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Department Hours
Pharmacy: 8 a.m. to 9 p.m. Monday-Friday; 9 a.m. to 6 p.m. Saturday & Sunday.
Flu shot schedule -
Monday-Friday 8 a.m.-9 p.m.
Walk-ins welcome.
Wine & Spirits: 8 a.m. to midnight daily
Store News
Flu Shot Schedule

Flu shots available 8 a.m. to 9 p.m. Monday-Friday. Walk-ins welcome.  Read more.

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Department Features

Learn more about the departments and services offered at your Des Moines Hy-Vee Drugstore and the store management.

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