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Ames Hy-Vee Drugstore

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At the intersection of Main and Clark, two blocks west of Highway 69/Duff Ave.

Open 7 a.m. to 8 p.m Monday through Friday; 9 a.m. to 5 p.m. Saturday; 10 a.m. to 4 p.m. Sunday. Closed Thanksgiving Day and Christmas Day.
Open other holidays with variable abreviated hours. Check for specific hours.

500 Main Street
Ames, IA 50010
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Phone Numbers:
Store: (515) 233-9855
Department Phone Numbers
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Online Refills
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Department Hours
Hy-Vee Drugstore Clinic: Monday through Friday 8 a.m. to 7 p.m.
Saturday 8 a.m. to 1 p.m.
Sunday closed
Pharmacy: Monday through Friday
8 a.m. to 8 p.m.
Saturday 9 a.m. to 5 p.m.
Sunday 10 a.m. to 4 p.m.
Closed holidays.
Store News
Cancer Awareness Merchandise

Check out our new line of cancer awareness merchandise: "They All Matter."  Read more.

Meet Our New Store Director

Stop in and welcome our new store director, Fred French.  Read more.

Check Out Our Pharmacy

Check out our Pharmacy - friendly service, exceptional care!  Read more.

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Calendar of Events
Visit the Hy-Vee Drugstore on Saturday, November 29

11/29/2014 9:00 a.m. - 5:00 p.m.
Stop into the Hy-Vee Drugstore while you are shopping in downtown Ames on Saturday, November 29. Read more.

Flavored Coffee and Food Sampling

12/6/2014 9:00 a.m. - 5:00 p.m.
Flavored coffee and food sampling Read more.

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Dietitian services
At Your Service

If you have a question or need an informed opinion, just ask your Hy-Vee dietitian.

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Department Features

Learn more about the departments and services offered at your Ames Hy-Vee Drugstore and the store management.

Hy-Vee Floral

No matter what your occasion is, casual to formal, your Hy-Vee caterers do it. Browse our selections for your next special event.

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